Isfahan Cardiovascular Research Center (ICRC) was approved by the Ministry of Health (MOH) in 1993 with the aim of performing research on cardiovascular diseases (CVD) prevention and health promotion to produce evidence that can be utilized for action. ICRC became a World Health Organization (WHO) collaborating center for research and training in CVD control, prevention and rehabilitation of cardiac patients in the Eastern Mediterranean Region since 2003. It was promoted to the cardiovascular research institute (CRI) in 2011 by the MOH. The main fields of research in CRI are in public health, clinical and basic sciences.