ISFAHAN CARDIOVASCULAR RESEARCH CENTER

Founder and Director: 
Nizal Sarrafzadegan, MD 
Director of Isfahan Cardiovascular Research Center, 
Isfahan University of Medical Sciences

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Brief Biography: 
Dr. Nizal Sarrafzadegan is Professor of Cardiology in Isfahan University of Medical Sciences in Iran. She is the founder director of Isfahan Cardiovascular Research Institute, a WHO collaborating center for research and training in the Eastern Mediterranean Region. She started her studies mainly on Cardiovascular Diseases (CVD) and it’s risk factors prevention, healthy lifestyle promotion with her team since 1993 and published more than 200 articles in local and international journals. Her academic career combines a clinical background with strong interest in public health and policy, she has numerous multidisciplinary collaborations with investigators internationally and has worked with the WHO on Non-Communicable Disease (NCD) prevention and health promotion as technical advisor or consultant. Dr. Sarrafzadegan has organized more than twenty international and local meetings on CVD or NCD prevention and control. 
Dr. Sarrafzadegan has been awarded several national, international and presidential awards as a distinguished researcher, professor, doctor or women on different occasions.
She is the principle investigator of the national plan of NCD prevention and control entitled “Isfahan Healthy Heart Program” in Iran that conducted between 2000-2006. She has an active role in capacity building in the fields of implementation research, knowledge transfer and private-public partnership for NCD/CVD prevention nationally and internationally.
 
Background
ICRC initiated its activities in 1987 with aim of performing research on CVD primary, secondary prevention and health promotion for information for action. In 1993, a new building was allocated to the center and in 1994, the Council for Promoting the Iranian Universities approved the center as Center for Cardiovascular Research (ICRC). In 2003, ICRC was selected as a collaborating center with the World Health Organization for the prevention, control, and rehabilitation of cardiovascular diseases in the Eastern Mediterranean Region. The center was promoted in 2011 to Cardiovascular Research Institute with several research centers.
The central goal of ICRC is to utilize the existent technology to perform community-oriented biomedical research, produce applicable results, and contribute to furthering community knowledge.
 
General Objectives
1. To carry out basic and clinical research in the field of Cardiovascular Diseases (CVDs) with a special reference to the epidemiological aspects of prevention and control of CVDs, Cerebrovascular Diseases (CeVDs) and their risk factors and related diseases. 
2. To collect, evaluate and circulate information from research on prevention of CVDs and CeVDs. 
3. To contribute to the development and transfer appropriate technology for prevention, diagnosis and treatment of CVDs and CeVDs in EMR. 
4. To produce and disseminate research-based information on CVDs, CeVDs and their related risk factors to WHO when requested. 
5. Education and training, including: research training, medical education in the fields of NCD prevention, control and rehabilitation. 
6. Coordination of activities carried out by several institutions on a given subject. 
7. Providing information and advice on scientific, technical and policy issues.
8. Developing a surveillance system for NCDs and monitoring the risk factors and incidence of CVD and CeVD, and gauging related behaviors, attitudes, skills and knowledge in the community at large. 
 
Published Books or Chapter Books 
1. Hennekers CH. H, Buring J.E. Epidemiology in Medicine (Translation), 1998.
2. Maghsoodloo. S. Cardiac Rehabilitation .Teimoorzadeh Publisher. (supervision) 2001.
3. Burgarella F. The HEARTBook. (translated), 2001.
4. Sarrafzadegan N, Sajadi F. Hypertension and diabetes prevalence, awareness, treatment and control in the Eastern Mediterranean Region: with special reference to Iran. Frontiers Cardiovascular Health. Edited by N.S.Dhalla, A. Chokalingam, H I Berkowitz & P.K.Singal. Kluwar Academic Publishers, Boston, 2003.
5. Sarrafzadegan N, et al. Effective strategies and actions for control and prevention of non-communicable diseases in Iran “Isfahan Healthy Heart Program”. (First IHHP Series Book), Isfahan University of Medical Sciences Publisher ,Isfahan , 2007. 
6. Sarrafzadegan N, Alikhassi H. Isfahan Healthy Heart Program from design to implementation (Second IHHP Series Book) ) ,Isfahan University of Medical Sciences Publisher ,Isfahan, 2008. 
7. Global Recommendations on Physical Activity for Health, World Health Organization, 2010 (peer reviewer)
8. Sarrafzadegan N. Educational Package of Isfahan Healthy Heart Program(3rd IHHP Series Book) Isfahan University of Medical Sciences Publisher ,Isfahan, 2011
9. Sarrafzadegan N, Rabiei K. Participation Compliance and Outcomes of Outpatient Cardiac Rehabilitation Programs Among Women in Low Resource Settings. Cardiac Rehabilitation, Nova Publisher Inc., US, 2010; Chapter 8:185-199
10. Planning, Implementation and Evaluation of Non-Communicable Diseases Prevention and Control. WHO Publisher, 2010. 
11. Sarrafzadegan N, Masoudkabir F.” Ethnicity and cardiovascular risk factors ”.The European Society of Cardiology (ESC) Textbook of Cardiovascular Medicine 3rd edition .Edited by Thomas Luscher, John Camm, Gerald Maurer and Patrick Serruys. OXFORD UNIVERSITY PRESS, 2017
12. Khosravi- Boroujeni H, Sarrafzadegan N. “Effect of dairy products consumption on heart health and cardio-metabolic risk factors”. Handbook of Nutrition in Heart Health. Edited by Ronald Ross Watson & Sherma Zibadi. Wageningen Academic Publisher, 2017
 
Faculty Members 
Full-time:
- Prof. Nizal Sarrafzadegan 
- Prof. Seddigheh Asgary
- Assist. Prof. Noushin Mohammadifard
- Prof. Ali Pourmoghaddas 
Part-time:
- Assoc. Prof. Marjan Mansourian 
- Assist. Prof. Golnaz Vaseghi
 
Researchers 
- Dr. Hamidreza Roohafza
- Dr. Katayoun Rabiei
- Dr. Mojgan Gharipour
- Dr. Maryam Boshtam
- Dr. Samaneh Mostafavi
- Mahtab Keshvari
- Firouzeh Sajjadi
- Maryam Maghroun
- Sonia Zarfeshani
- Hassan Alikhassi
 
Existing equipment
Reliable and calibrated arm and ABI blood pressure measuring devices, and 24-hour Hear monitoring Holter in this center, also patients' access to the center’s clinic services and clinical laboratory.
Lab Equipment:
 
Main laboratory equipment: Research; Isfahan Cardiovascular Research Center
Row  name  Abbreviated name  Function
1 Gas Chromatography GC Assessment and isolation of volatile substances without decomposition
2 Spectrophotometer  Spect  Measurement of chemicals by optical absorption density
3 Ultracentrifuge  Ultra  Isolation of substances at high speed
4 Fraction collector    Collection of different fractions from a solution 
5 Peristaltic pump    Pumping desirable volumes of liquids as required
6 Homogenizer    Homogenizing plant and animal tissues 
7 Ultrasonic Baths    Cleaning objects in the shortest time
8 PH-meter   Measurement of PH of  buffer and solutions 
9 Soxhlet extractor    Isolation of the desired compositions using the least amount of solvent 
10 Gel Dryer    Agarose or polyacrylamide gel dryer  
11 Incubator    Culture and growth of laboratory samples at a specific temperature 
12 Digital balance    Weighing materials 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Main laboratory equipment: Genetics- Isfahan Cardiovascular Research Center

ROW name Abbreviated name  Function
1 UV detector  UV tec Observation of agarose gel using UV
2 PCR thermocycler  PCR Specific DNA proliferation 
3 Microcentrifuge   High-speed isolation of materials 
4 CO2 incubator    Culture and growth of laboratory samples
5 Laminar flow    Cell culture and RNA extraction 
6 Shaker    Mixing and preparation of solutions
7 Gel electrophorus    DNA assessment 
8 Scale    Weighing laboratory powders 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Main laboratory equipment: Clinical- Isfahan Cardiovascular Research Center

Row  name  Abbreviated name  Function
1

Automatic Analyzer

Hitachi 902  

  Assessment of biochemical tests
2 Caretium    Assessor of sodium, potassium, serum calcium, and urine 
3 Sysmex kx21N   Counting blood cells 
4 Sysmex kx1000   Counting blood cells 
5 Sysmex ca-50   PTT, PT
6

ESR device

(Caretium)

  Assessment of RBC sedimentation test
7 Microscope    -
8 Stat-fax 2100   Assessment of hormone test 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Available Facilities 

- Joint collaboration with other centers and institutions:

WHO collaborating center: In 2003, ICRC became a World Health Organization (WHO) collaborating center for research and training in CVD prevention, management and control as well as rehabilitation of cardiac patients in the Eastern Mediterranean Region also this center has joint collaboration with other international organization e.g. International Atherosclerosis Society (IAS), World Heart Federation (WHF),…
- Independent Research Budget
- Getting Grants from International and National Sources
- Performing many multicentric studies with many International & National academic centers and Institutes 
- Educational services: Admission of students majoring in medicine for Ph.D. by research program from qualified GPs, nursing MSc, public health MSc ….
- Research services: 
- Advice and counseling on theses of medical and paramedical students, and theses of cardiovascular residents 
- Encouragement and use of researchers, residents, and fellowships of cardiovascular department, residents and students in the field of prevention, control, and treatment of cardiovascular diseases
- Database for large projects (Isfahan Healthy Heart Program (IHHP), Isfahan Cohort study (ICS)-Surveillance- PURE Study rehabilitation- hypertension studies, salt studies, Air pollution studies …)
- Preparation of relevant guidelines.
 
Clinical Services:
- Clinic
- Clinical Laboratory 
 
Address:
Isfahan Cardivascular Research Center, Cardiovascular Research Institute,
Shahid Rahmani Alley, Moshtagh Sevom St.,
Isfahan, Iran
PO Box: 81465-1148 
Tel: +98- 3136115313
Fax: +98- 3136115310
Email: